In total, there will be about 12,000 athletes packed into Franklin Field at the University of Pennsylvania, not including the crowd, which will feature people from Jamaica, Britain and Canada.
Penn State has been competing at the Relays since 1896, while Penn State track and field head coach Harry Groves has been attending the meet for the last 41 years.
Groves has watched the Relays swell to include women's track and become an important cog in an athlete's development.
"The quality has increased tremendously in the whole sport," Groves said. "The facilities are so much better than they used to be and so have the performances."
He added that the meet has become more competitive because of the number of teams that are participating. Although the Relays place an emphasis on individuals, the relay events are ultra competitive because they throws together some of the best athletes in the world.
Athletes can compete at different levels at the Relays such as the collegiate level or the Championship of America level. Winning at the Championship of America level immediately propels you onto the national stage.
"It is one of the high points of the season," Groves said. "If you win here, you are one of the best in the U.S., especially in the relays."