Penn State as a team turned the ball over 11 times in the first half, while causing only eight.
In the second half the Lady Lions coughed it up only once, created nine, and shot 60 percent for a season-high of 48 points in a half.
"I went in at halftime and told them we overcoached," Penn State coach Rene Portland said. "I told them they needed to just play basketball. In the first half we had them thinking too much.
"In the second half I thought the press on the ball really picked up, and that made a major difference because it forced some more turnovers and they had fun playing basketball."
With Lawless on the bench for nearly half of the game, Penn State was able to penetrate the paint, getting easy baskets and regular trips to the foul line. Penn State outscored Purdue 32-14 in the paint, with Brown asserting herself as presence inside.
She had seven points, eight rebounds and four blocks.
With last night's win, the Lady Lions evened the all-time series with the Boilermakers, 14-14.
It was also the fifth straight time Penn State beat Purdue at home, dating back to 1999.
Penn State hosts No. 8 Michigan State on Sunday for "Rene Sunday," in which Portland will be honored before the game for her 25 years as head coach at Penn State.
A win over the Spartans would be the fifth win over a top-25 team this season and could also get the Lady Lions back in the rankings for the first time since the second week of the season.