The bands performing at the show include Axum, E.S. Whitefisch, Emily's Toybox and the Carmats.
Organizers fear there might be a small turnout because of the new state liquor law, which is threatening the existence of all-ages shows at local venues with a liquor license.
The new law requires that there be one chaperone over the age of 25 for every five under-age patrons.
"The law hurts us from helping a charitable event," said Jason "Fish" Miller, a QWK Rock disc jockey. "Affecting the amount of people affects the amount of money raised."
Axum's frontman, Tim McKenna, said he is concerned people will be turned away at the door if there aren't enough chaperones.
"It's going to kill the crowd," McKenna said.
"But basically I'm not going to worry, because QWK Rock puts on a good show."
Mike Wise, lead singer of Emily's Toybox, said he fears the word "benefit" will scare people away.
The band has played the benefit show for the past three years, and Wise said crowds are smaller compared to regular shows.
"We do it out of the goodness of our hearts," said Wise, adding that a benefit takes money away from the band, not the fans.
Sarah Tomlinson (junior-marketing), an event organizer, said past Thon benefit shows have raised more than $1,000. But hopes of reaching that figure this year are uncertain because of the new liquor law, she said.
"Not even the Crowbar knows how it's being enforced," she said. "It's a hazy area."
Though organizers found some chaperone volunteers, they are still looking for more to allow an 18-and-over concert. Tickets are being sold at the door for $5. Doors open at 8 p.m. and Axum will start the show at 9.